Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

doi:10.1172/JCI152386

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Article

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

The Journal of clinical investigation - 1 Dec 2021

Nakanishi Tomoko, Pigazzini Sara, Degenhardt Frauke, Cordioli Mattia, Butler-Laporte Guillaume, Maya-Miles Douglas, Bujanda Luis, Bouysran Youssef, Niemi Mari Ek, Palom Adriana, Ellinghaus David, Khan Atlas, Martínez-Bueno Manuel, Rolker Selina, Amitrano Sara, Roade Tato Luisa, Fava Francesca, Spinner Christoph D, Prati Daniele, Bernardo David, Garcia Federico, Darcis Gilles, Fernández-Cadenas Israel, Holter Jan Cato, Banales Jesus M, Frithiof Robert, Kiryluk Krzysztof, Duga Stefano, Asselta Rosanna, Pereira Alexandre C, Romero-Gómez Manuel, Nafría-Jiménez Beatriz, Hov Johannes R, Migeotte Isabelle, Renieri Alessandra, Planas Anna M, Ludwig Kerstin U, Buti Maria, Rahmouni Souad, Alarcón-Riquelme Marta E, Schulte Eva C, Franke Andre, Karlsen Tom H, Valenti Luca, Zeberg Hugo, Richards J Brent, Ganna Andrea

Abstract excerpt

BackgroundThere is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition.MethodsWe combined individual level data from 13,888 COVID-19 patients (n = 7185 hospitalized) from 17 cohorts in 9 countries to assess the associ...

Topics

Age Factors
Aged
Aged, 80 and over
Alleles
COVID-19
Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Frequency

Genetic Loci

Humans

Male

Middle Aged

Patient Acuity

Polymorphism, Genetic

Risk Factors

SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 34597274
DOI: 10.1172/JCI152386
PMCID: PMC8631592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-34597274-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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