Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens.

doi:10.3389/fimmu.2026.1829115

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Article

Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens.

Frontiers in immunology - 1 Jan 2026

De La Morena-Barrio María Eugenia, Van Den Rym Ana, Escorial Sanz Olga, Corvillo Fernando, García-Sánchez Rosario, González-Sánchez Laura, Muñoz-Barrera Adrián, González-Montelongo Rafaela, Lorenzo-Salazar José Miguel, Flores Carlos, de Andrés-Martín Ana, Rodríguez-Gallego Carlos, Allende Luis, Alsina Laia, Sánchez-Ramón Silvia, López-Collazo Eduardo, López-Trascasa Margarita, Sánchez-Corral Pilar, Pérez de Diego Rebeca, Corral de la Calle Javier, López-Lera Alberto

Abstract excerpt

Introduction: The first wave of Coronavirus disease 2019 (COVID-19), driven by the global emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), severely affected Spain with high infection and mortality rates across the country. Although numerous common and rare genetic variants affecting immune-related pathways have been associated with susceptibility to infection and severe disease, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42367796
DOI: 10.3389/fimmu.2026.1829115
PMCID: PMC13293796

Genes

C3
C1R
C8A
CFH
CFHR4
FCN2
FCN3
MASP2

Variants

rs117402032
rs117402032
rs7255087
rs2230199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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