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Article

Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19.

Journal of autoimmunity - 1 Feb 2021

Valenti Luca, Griffini Samantha, Lamorte Giuseppe, Grovetti Elena, Uceda Renteria Sara Colonia, Malvestiti Francesco, Scudeller Luigia, Bandera Alessandra, Peyvandi Flora, Prati Daniele, Meroni Pierluigi, Cugno Massimo

Abstract excerpt

BACKGROUND: Genetic variation at a multigene cluster at chromosome 3p21.31 and the ABO blood group have been associated with the risk of developing severe COVID-19, but the mechanism remains unclear. Complement activation has been associated with COVID-19 severity. OBJECTIVE: The aim of this study was to examine whether chromosome 3p21.31 and the ABO variants are linked to the activation of the complement cascade...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33453462
DOI: 10.1016/j.jaut.2021.102595
PMCID: PMC7796659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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