The effect of interleukin-6 signaling on severe malaria: A Mendelian randomization analysis.

doi:10.1016/j.ijid.2023.02.008

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Article

The effect of interleukin-6 signaling on severe malaria: A Mendelian randomization analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2023

Hamilton Fergus, Mitchell Ruth E, Constantinescu Andrei, Hughes David, Cunnington Aubrey, Ghazal Peter, Timpson Nicholas J

Abstract excerpt

OBJECTIVES: Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown if this association is causal. METHODS: A single nucleotide polymorphism (SNP; rs2228145) in the IL-6 receptor was chosen as a genetic variant that is known to alter IL-6...

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Identifiers

PMID: 36801374
DOI: 10.1016/j.ijid.2023.02.008
PMCID: PMC10728776

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