Article
Causal effect of severe and non-severe malaria on dyslipidemia in African Ancestry individuals: A Mendelian randomization study.
Annals of human genetics - 1 Jul 2025
Traore Mariam, Sangare Harouna, Diabate Oudou, Diawara Abdoulaye, Cissé Cheickna, Nashiru Oyekanmi, Li Jian, Shaffer Jeffrey, Wélé Mamadou, Doumbia Seydou, Chikowore Tinashe, Soremekun Opeyemi, Fatumo Segun
Abstract excerpt
BACKGROUND: Dyslipidemia is becoming prevalent in Africa, where malaria is endemic. Observational studies have documented the long-term protective effect of malaria on dyslipidemia; however, these study designs are prone to confounding. Therefore, we used Mendelian randomization (MR, a method robust to confounders and reverse causation) to determine the causal effect of severe malaria (SM) and the recurrence of...
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