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Article

Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.

Cancer research - 14 Apr 2023

Malik Navdeep, Kim Young-Im, Yan Hualong, Tseng Yu-Chou, du Bois Wendy, Ayaz Gamze, Tran Andy D, Vera-Ramirez Laura, Yang Howard, Michalowski Aleksandra M, Kruhlak Michael, Lee Maxwell, Hunter Kent W, Huang Jing

Abstract excerpt

Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated cancer pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pairs from passenger pairs remains challenging. Here, we designed an integrated omics approach to identify driver gene pairs by leveraging genetic interaction analyses...

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Identifiers

PMID: 36799863
DOI: 10.1158/0008-5472.CAN-22-2525
PMCID: PMC10106426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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