Article

Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancer

2026-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Triple negative breast cancer (TNBC) patients harboring residual cancer burden following completion of conventional neoadjuvant chemo-immunotherapy regimens have poor relapse-free and overall survival rates and limited therapeutic options. We and others have demonstrated that mitochondrial function is required for the survival of chemo-refractory TNBC. Here, we define the mitochondrial translati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61eb97a3-5491-5fc2-9279-9f93bfee4b6e
DOI: 10.64898/2026.03.23.712647

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancerDOI 10.64898/2026.03.23.712647Read

Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatmentSemantic proximity Read

PET117 Modulates Mitochondrial-encoded COX1 Translation by stabilizing TACO1Semantic proximity Read

Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.Semantic proximity Read

AADAT-Driven Metabolic Control of Malate and CoQ <sub>10</sub> Shapes Immune Evasion in Triple-Negative Breast CancerSemantic proximity Read

DRP1-mediated mitochondrial fission integrates growth hormone signaling with metabolic and stress adaptation in triple-negative breast cancerSemantic proximity Read

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphateSemantic proximity Read

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibitionSemantic proximity Read

Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancerSemantic proximity Read

Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in MelanomaSemantic proximity Read

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibitionSemantic proximity Read

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistanceSemantic proximity Read

Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastomaSemantic proximity Read