Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2015

Shen Liangliang, O'Shea John M, Kaadige Mohan R, Cunha Stéphanie, Wilde Blake R, Cohen Adam L, Welm Alana L, Ayer Donald E

Abstract excerpt

Triple-negative breast cancers (TNBCs) are aggressive and lack targeted therapies. Understanding how nutrients are used in TNBCs may provide new targets for therapeutic intervention. We demonstrate that the transcription factor c-Myc drives glucose metabolism in TNBC cells but does so by a previo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Cellular Reprogramming

Share to Glucose

Share to Glycolysis

Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25870263
DOI: 10.1073/pnas.1501555112
PMCID: PMC4418882

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25870263-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.PMID 25870263Read ↗

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic bindingSemantic proximity Read ↗

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic bindingSemantic proximity Read ↗

TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype.Semantic proximity Read ↗

TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancerSemantic proximity Read ↗

Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasisSemantic proximity Read ↗

Overexpression of Proteins Involved in Mitotic Progression Underlies High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast CancerSemantic proximity Read ↗

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphateSemantic proximity Read ↗

TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in Triple-Negative Breast CancerSemantic proximity Read ↗

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast CancerSemantic proximity Read ↗

CTPS1 Promotes Malignant Progression of Triple-Negative Breast Cancer With Transcriptional Activation By YBX1Semantic proximity Read ↗

Transcriptomic profile of <i>MTUS1</i> -low TNBC reveals candidate therapeutic strategiesSemantic proximity Read ↗

Glucose Metabolic Reprogramming in Thyroid Cancer: Underlying Molecular Mechanisms and Links to Progression and Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.