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Article

Protein quantitative trait locus analysis in African American and non-Hispanic White individuals.

Genome biology - 10 Jul 2025

Cai Yanwei, Johnson Mari, Haessler Jeffrey, Molstad Aaron J, Hwang Shih-Jen, Joehanes Roby, Murabito Joanne M, Tahir Usman A, Franceschini Nora, Gerszten Robert E, Sun Wei, Levy Daniel, Raffield Laura M, Kooperberg Charles, Hsu Li, Reiner Alexander P

Abstract excerpt

BACKGROUND: Substantial efforts have been dedicated to exploring the link between genetic regulation and the proteome, informing studies of complex trait mechanisms. Most of these efforts have been limited to populations of European ancestry. RESULTS: We conduct an Olink protein quantitative trait locus (pQTL) analysis on 1245 proteins involving 1033 self-identified African American (AA) and 1764 non-Hispanic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40640959
DOI: 10.1186/s13059-025-03671-x
PMCID: PMC12243311

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