Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway.

Journal of neuroinflammation - 16 Jun 2020

Li Sichen, Shi Yuan, Liu Peixi, Song Yaying, Liu Yingjun, Ying Lingwen, Quan Kai, Yu Guo, Fan Zhiyuan, Zhu Wei

Abstract excerpt

BACKGROUND: The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a 5' AMP-activated protein kinase (AMPK) agonist that has a protective effect on vasculature. The present study investigated whether metformin modulates VSMC phenotype switching via the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyl-CoA Carboxylase
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Intracranial Aneurysm

Share to Metformin

Share to Muscle, Smooth, Vascular

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 32546267
DOI: 10.1186/s12974-020-01868-4
PMCID: PMC7298751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway.PMID 32546267Read ↗

Vascular smooth muscle cells in intracranial aneurysms.Semantic proximity Read ↗

Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK–SIRT1–PGC-1α AxisSemantic proximity Read ↗

Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice.Semantic proximity Read ↗

Shear Stress Induces Phenotypic Modulation of Vascular Smooth Muscle Cells via AMPK/mTOR/ULK1-Mediated Autophagy.Semantic proximity Read ↗

Salidroside inhibits platelet-derived growth factor BB-induced human aortic smooth muscle cell phenotype switching via PDGFR-β/AKT/mTOR/HIF-1α pathway 1Semantic proximity Read ↗

SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm.Semantic proximity Read ↗

Dexmedetomidine Alleviates Inflammatory Response and Oxidative Stress Injury of Vascular Smooth Muscle Cell via α2AR/PI3K/AKT Pathway in Intracranial AneurysmSemantic proximity Read ↗

Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms.Semantic proximity Read ↗

Phenotypic switching of vascular smooth muscle cells in animal model of rat thoracic aortic aneurysm.Semantic proximity Read ↗

PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats.Semantic proximity Read ↗

Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.