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Article

Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice.

Atherosclerosis - 1 Mar 2020

Lai Chao-Han, Chang Ching-Wen, Lee Fang-Tzu, Kuo Cheng-Hsiang, Hsu Jong-Hau, Liu Chung-Pin, Wu Hua-Lin, Yeh Jwu-Lai

Abstract excerpt

BACKGROUND AND AIMS: Inflammation, oxidative stress, matrix degradation, medial calcification and vascular smooth muscle cell (VSMC) loss are prominent features in abdominal aortic aneurysm (AAA). VSMC phenotypic switch to a proinflammatory state and VSMC apoptosis could be targetable mechanisms implicated in the pathogenesis of AAA formation. Herein, we investigated the hypothesis that a xanthine derivative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout, ApoE

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 32059119
DOI: 10.1016/j.atherosclerosis.2020.01.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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