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Article

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.

Molecular psychiatry - 1 Sept 2024

Crouse Jacob J, Park Shin Ho, Byrne Enda M, Mitchell Brittany L, Scott Jan, Medland Sarah E, Lin Tian, Wray Naomi R, Martin Nicholas G, Hickie Ian B

Abstract excerpt

The dominant ('general') version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year,...

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Identifiers

PMID: 38575805
DOI: 10.1038/s41380-024-02492-x
PMCID: PMC11420070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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