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Article

A direct test of the diathesis-stress model for depression.

Molecular psychiatry - 1 Jul 2018

Colodro-Conde L, Couvy-Duchesne B, Zhu G, Coventry W L, Byrne E M, Gordon S, Wright M J, Montgomery G W, Madden P A F, Ripke S, Eaves L J, Heath A C, Wray N R, Medland S E, Martin N G

Abstract excerpt

The diathesis-stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the...

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Identifiers

PMID: 28696435
DOI: 10.1038/mp.2017.130
PMCID: PMC5764823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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