Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.

Translational psychiatry - 30 Jan 2023

Wang Rujia, Hartman Catharina A, Snieder Harold

Abstract excerpt

It is unclear whether and to what extent stress-related exposures moderate the effects of polygenic risk scores (PRSs) on depression and anxiety. We aimed to examine such moderation effects for a variety of stress-related exposures on depression and anxiety. We included 41,810 participants with both genome-wide genetic data and measurements of depression and anxiety in the Lifelines Cohort Study. Current...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Cohort Studies
Share to Depression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Source

Open in PubMed Open full text

Identifiers

PMID: 36717542
DOI: 10.1038/s41398-023-02327-3
PMCID: PMC9886926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.PMID 36717542Read ↗

A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study.Semantic proximity Read ↗

Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations.Semantic proximity Read ↗

A direct test of the diathesis-stress model for depression.Semantic proximity Read ↗

Unraveling the interaction between stress and genetic risk in psychiatric disorders: Challenges, mechanisms, and new advances.Semantic proximity Read ↗

Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.Semantic proximity Read ↗

Polygene by environment interactions predicting depressive outcomes.Semantic proximity Read ↗

Three shades of gloom: investigating the genetic background of current depressive symptoms associated with different severity of current stress exposure in a general population.Semantic proximity Read ↗

Decoding depression by exploring the exposome-genome edge amidst COVID-19 lockdownSemantic proximity Read ↗

The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Semantic proximity Read ↗

Genetic opportunities for psychiatric epidemiology: on life stress and depression.Semantic proximity Read ↗

Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study.Semantic proximity Read ↗

Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.