Article
Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.
Translational psychiatry - 30 Jan 2023
Wang Rujia, Hartman Catharina A, Snieder Harold
Abstract excerpt
It is unclear whether and to what extent stress-related exposures moderate the effects of polygenic risk scores (PRSs) on depression and anxiety. We aimed to examine such moderation effects for a variety of stress-related exposures on depression and anxiety. We included 41,810 participants with both genome-wide genetic data and measurements of depression and anxiety in the Lifelines Cohort Study. Current...
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