Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

doi:10.1038/s41380-019-0546-6

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

Molecular psychiatry - 1 Jul 2020

Coleman Jonathan R I, Peyrot Wouter J, Purves Kirstin L, Davis Katrina A S, Rayner Christopher, Choi Shing Wan, Hübel Christopher, Gaspar Héléna A, Kan Carol, Van der Auwera Sandra, Adams Mark James, Lyall Donald M, Choi Karmel W, Dunn Erin C, Vassos Evangelos, Danese Andrea, Maughan Barbara, Grabe Hans J, Lewis Cathryn M, O'Reilly Paul F, McIntosh Andrew M, Smith Daniel J, Wray Naomi R, Hotopf Matthew, Eley Thalia C, Breen Gerome

Abstract excerpt

Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed....

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PMID: 31969693
DOI: 10.1038/s41380-019-0546-6
PMCID: PMC7305950

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