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Article

PEA-15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia.

Journal of the American Heart Association - 11 Sept 2017

Greig Fiona H, Kennedy Simon, Gibson George, Ramos Joe W, Nixon Graeme F

Abstract excerpt

BACKGROUND: Neointimal hyperplasia following angioplasty occurs via vascular smooth muscle cell proliferation. The mechanisms involved are not fully understood but include mitogen-activated protein kinases ERK1/2 (extracellular signal-regulated kinases 1 and 2). We recently identified the intracellular mediator PEA-15 (phosphoprotein enriched in astrocytes 15) in vascular smooth muscle cells as a regulator of...

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Identifiers

PMID: 28893763
DOI: 10.1161/JAHA.117.006936
PMCID: PMC5634313

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