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Article

Functional Diversity of p53 in Human and Wild Animals

12 Mar 2019

Abstract excerpt

The common understanding of p53 function is a genome guardian, which is activated by diverse stresses stimuli and mediates DNA repair, apoptosis and cell cycle arrest. Increasing evidence has demonstrated p53 new cellular functions involved in abundant endocrine and metabolic response for maintaining homeostasis. However, TP53 is frequently mutant in human cancers, and the mutant p53 (Mut-p53) turns to an “evil”...

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Identifiers

PMID: 30915036
DOI: 10.3389/fendo.2019.00152

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