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The Δ133p53 Isoforms, Tuners of the p53 Pathway

18 Nov 2020

Abstract excerpt

The TP53 gene is a critical tumor suppressor and key determinant of cell fate which regulates numerous cellular functions including DNA repair, cell cycle arrest, cellular senescence, apoptosis, autophagy and metabolism. In the last 15 years, the p53 pathway has grown in complexity through the discovery that TP53 differentially expresses twelve p53 protein isoforms in human cells with both overlapping and unique...

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PMID: 33218139
DOI: 10.3390/cancers12113422

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