p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat.

Abstract excerpt

p53 is a transcription factor involved in maintaining genomic integrity by regulating genes involved in cell cycle arrest, DNA repair, and programmed cell death. Various post transcriptional modifications result in activated p53 with varying binding affinity to its targets. The other members of the p53 family (p63, p73) and associated proteins also contribute to the specificity of gene activation resulting in the...

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• Cell Cycle
• Cloning, Molecular
• DNA Repair
• Hypoxia
• Mutagenesis