Adaptive homeostasis and the p53 isoform network.

doi:10.15252/embr.202153085

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Article

Adaptive homeostasis and the p53 isoform network.

EMBO reports - 6 Dec 2021

Mehta Sunali, Campbell Hamish, Drummond Catherine J, Li Kunyu, Murray Kaisha, Slatter Tania, Bourdon Jean-Christophe, Braithwaite Antony W

Abstract excerpt

All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour suppressor maintains cell and organ integrity and functions in response to homeostasis disruptors (stresses) such as infection, metabolic alterations and cellular damage. Thus, p53 plays a fundamental physiological role in maintaining organismal...

Topics

Animals
Genes, p53
Homeostasis
Infections
Mutation
Protein Isoforms
Stress, Physiological
Tumor Suppressor Protein p53

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Identifiers

PMID: 34779563
DOI: 10.15252/embr.202153085
PMCID: PMC8647153

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