Article
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
19 Sept 2016
Abstract excerpt
A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here, we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the...
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