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Uncoupling elephant TP53 and cancer

27 Jun 2023

Abstract excerpt

Elephant testicles do not descend, with implications for sperm production being hot enough to compromise germline DNA replication/repair. Uniquely, elephants also possess 20 copies of a gene encoding for the p53 protein. Did elephants evolve multiplication of the TP53 gene complex to protect their germline rather than to fight cancer?

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Identifiers

PMID: 37385845
DOI: 10.1016/j.tree.2023.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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