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Cancer suppression and the evolution of multiple retrogene copies of TP53 in elephants: A re‐evaluation

12 Apr 2022

Abstract excerpt

Abstract Evolving to become bigger and/or longer lived should increase cancer susceptibility, but this predicted increase is not observed, a contradiction named Peto's paradox. A solution is that cancer suppression evolves to minimize cancer susceptibility, and the discovery of 19 retrogene (RTG) copies of the tumor suppressor gene TP53 in the African elephant (Loxodonta africana) is increasingly cited as a...

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PMID: 35603034
DOI: 10.1111/eva.13383

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