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Article

Convergent TP53 loss and evolvability in cancer.

BMC ecology and evolution - 25 Sept 2023

Mansur Marcela Braga, Greaves Mel

Abstract excerpt

Cancer cell populations evolve by a stepwise process involving natural selection of the fittest variants within a tissue ecosystem context and as modified by therapy. Genomic scrutiny of patient samples reveals an extraordinary diversity of mutational profiles both between patients with similar cancers and within the cancer cell population of individual patients. Does this signify highly divergent evolutionary...

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Identifiers

PMID: 37743495
DOI: 10.1186/s12862-023-02146-6
PMCID: PMC10518978

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