Article
Detection of BRAF mutations in malignant melanoma and colorectal cancer by SensiScreen® FFPE BRAF qPCR assay.
PloS one - 1 Jan 2023
Sørensen Anna Lahn, Guldmann-Christensen Mariann, Børgesen Michael, Petersen Rasmus Koefoed, Flugt Katharina, Duelund Julie Mejer Holmgaard, Kyneb Majbritt Hauge, Lorenzen Jan, Pipó-Ollé Emma, Epistolio Samantha, Riva Alice, Dazio Giulia, Merlo Elisabetta, Meyer Tine, Christensen Ulf Bech, Frattini Milo
Abstract excerpt
Mutations in BRAF exon 15 lead to conformational changes in its activation loops, resulting in constitutively active BRAF proteins which are implicated in the development of several human cancer types. Different BRAF inhibitors have been developed and introduced in clinical practice. Identification of BRAF mutations influences the clinical evaluation, treatment, progression and for that reason a sensitive and...
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