Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SensiScreen®KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations.

PloS one - 1 Jan 2017

Riva Alice, BØrgesen Michael, Guldmann-Christensen Mariann, Hauge Kyneb Majbritt, Voogd Kirsten, Andersen Christina, Epistolio Samantha, Merlo Elisabetta, Yding Wolff Tine, Hamilton-Dutoit Stephen, Lorenzen Jan, Christensen Ulf Bech, Frattini Milo

Abstract excerpt

Activating mutations in codon 12 and codon 13 of the KRAS (Kirsten rat sarcoma viral oncogene homolog) gene are implicated in the development of several human cancer types and influence their clinical evaluation, treatment and prognosis. Numerous different methods for KRAS genotyping are currently available displaying a wide range of sensitivities, time to answer and requirements for laboratory equipment and user...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to DNA, Neoplasm

Share to Multiplex Polymerase Chain Reaction

Share to Proto-Oncogene Proteins p21(ras)

Share to Real-Time Polymerase Chain Reaction

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 28636636
DOI: 10.1371/journal.pone.0178027
PMCID: PMC5479524

Genes

KRAS
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SensiScreen®KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations.PMID 28636636Read ↗

Eprobe-mediated screening system for somatic mutations in the KRAS locus.Semantic proximity Read ↗

KRAS mutations detection methodology: from RFLP to CRISPR/Cas based methods.Semantic proximity Read ↗

Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practiceSemantic proximity Read ↗

Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal CancerSemantic proximity Read ↗

High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue.Semantic proximity Read ↗

A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical SettingSemantic proximity Read ↗

KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing.Semantic proximity Read ↗

Performance evaluation comparison of 3 commercially available PCR-based KRAS mutation testing platforms.Semantic proximity Read ↗

A PNA-mediated clamping PCR for routine detection of KRAS mutations in colorectal carcinoma.Semantic proximity Read ↗

KRAS mutation testing in colorectal cancer: comparison of the results obtained using 3 different methods for the analysis of codons G12 and G13.Semantic proximity Read ↗

Detection of BRAF mutations in malignant melanoma and colorectal cancer by SensiScreen® FFPE BRAF qPCR assay.Semantic proximity Read ↗

The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.