Multi-center evaluation of the novel fully-automated PCR-based Idylla™ BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma.

doi:10.1016/j.yexmp.2015.09.004

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Article

Multi-center evaluation of the novel fully-automated PCR-based Idylla™ BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma.

Experimental and molecular pathology - 1 Dec 2015

Melchior Linea, Grauslund Morten, Bellosillo Beatriz, Montagut Clara, Torres Erica, Moragón Ester, Micalessi Isabel, Frans Johan, Noten Veerle, Bourgain Claire, Vriesema Renske, van der Geize Robert, Cokelaere Kristof, Vercooren Nancy, Crul Katrien, Rüdiger Thomas, Buchmüller Diana, Reijans Martin, Jans Caroline

Abstract excerpt

The advent of BRAF-targeted therapies led to increased survival in patients with metastatic melanomas harboring a BRAF V600 mutation (implicated in 46-48% of malignant melanomas). The Idylla(™) System (Idylla(™)), i.e., the real-time-PCR-based Idylla(™) BRAF Mutation Test performed on the fully-automated Idylla(™) platform, enables detection of the most frequent BRAF V600 mutations (V600E/E2/D, V600K/R/M) in...

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PMID: 26407762
DOI: 10.1016/j.yexmp.2015.09.004

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BRAF

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