Article
A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma.
Scientific reports - 1 Jan 2013
Richter Anna, Grieu Fabienne, Carrello Amerigo, Amanuel Benhur, Namdarian Kateh, Rynska Aleksandra, Lucas Amanda, Michael Victoria, Bell Anthony, Fox Stephen B, Hewitt Chelsee A, Do Hongdo, McArthur Grant A, Wong Stephen Q, Dobrovic Alexander, Iacopetta Barry
Abstract excerpt
Melanoma patients with BRAF mutations respond to treatment with vemurafenib, thus creating a need for accurate testing of BRAF mutation status. We carried out a blinded study to evaluate various BRAF mutation testing methodologies in the clinical setting. Formalin-fixed, paraffin-embedded melanoma samples were macrodissected before screening for mutations using Sanger sequencing, single-strand conformation...
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