Article
Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma.
The Journal of molecular diagnostics : JMD - 1 Sept 2007
Spittle Cynthia, Ward M Renee, Nathanson Katherine L, Gimotty Phyllis A, Rappaport Eric, Brose Marcia S, Medina Angelica, Letrero Richard, Herlyn Meenhard, Edwards Robin H
Abstract excerpt
Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling; therefore, the development of RAF kinase inhibitors for targeted therapy is being actively pursued. A methodology that allows sensitive, cost-effective,...
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