Article
Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.
Molecular diagnosis & therapy - 1 Apr 2017
Franczak Claire, Salleron Julia, Dubois Cindy, Filhine-Trésarrieu Pierre, Leroux Agnès, Merlin Jean-Louis, Harlé Alexandre
Abstract excerpt
BACKGROUND: Metastatic or unresectable melanoma is a serious and deadly disease. Anti-BRAF and immunotherapy improved overall survival in patients with metastatic disease. Thus, BRAF genotyping is important to choose the right therapy. METHODS: In our study, we assessed and compared BRAF mutations in 59 formalin-fixed and paraffin-embedded tumor samples of patients with metastatic melanoma with next-generation...
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