Article
Effect of common OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 polymorphisms on perioperative analgesic and propofol demands on patients subjected to thyroidectomy surgery.
Pharmacological reports : PR - 1 Apr 2023
Soultati Ioanna, Ntenti Charikleia, Tsaousi Georgia, Pourzitaki Chryssa, Gkinas Dimitris, Thomaidou Evanthia, Alexandrakis Spiros, Papavramidis Theodosios, Goulas Antonis
Abstract excerpt
BACKGROUND: Perioperative anesthetic and/or analgesic demand present considerable variation, and part of that variation appears to be genetic in origin. Here we investigate the impact of common polymorphisms in OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 genes, on the intra-operative consumption of remifentanil and propofol, as well as the postoperative analgesic needs, in patients subjected to thyroidectomy surgery....
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