Article
Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese patients with cancer pain.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Gong Xiao-Di, Wang Jiong-Yi, Liu Feng, Yuan Hai-Hua, Zhang Wen-Ying, Guo Yue-Hui, Jiang Bin
Abstract excerpt
BACKGROUNDS: Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain. This study aimed to investigate the association of both two polymorphisms with opioid requirements in Chinese patients with cancer pain. METHODS: The genotypes...
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