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Article

Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study.

European journal of anaesthesiology - 1 Jul 2018

Aubrun Frédéric, Zahr Noël, Langeron Olivier, Boccheciampe Nicolas, Cozic Nathalie, Belin Lisa, Hulot Jean-Sebastien, Khiami Frederic, Riou Bruno

Abstract excerpt

BACKGROUND: Among the various factors that may influence the pharmacological response to opioids, genetic polymorphisms [single nucleotide polymorphisms (SNP)] have generated some interest. OBJECTIVES: To examine the influence on morphine dose requirements and adverse events in the postoperative period of four SNP [opioid receptor mu1 (OPRM1), ATP-binding cassette subfamily B, member 1 (ABCB1) ex-21 and ex-26,...

Read the complete abstract on PubMed

Topics

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Share to Aged, 80 and over
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Catechol O-Methyltransferase

Share to Morphine

Share to Pain Management

Share to Pain, Postoperative

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 29474345
DOI: 10.1097/EJA.0000000000000793

Genes

ABCB1
COMT
OPRM1

Variants

rs1799971
rs1799971
rs1799971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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