Article
A single nucleotide polymorphism-based formula to predict the risk of propofol TCI concentration being over 4 µg mL-1 at the time of loss of consciousness.
The pharmacogenomics journal - 1 Mar 2022
Zheng Zhuoling, Xue Faling, Wang Haini, He Yongqi, Zhang Lingyi, Ma Wudi, Zhang Caibin, Guan Yanping, Ye Fang, Wen Yongzi, Li Xiaoyan, Huang Min, Huang Wenqi, Wang Zhongxing, Li Jiali
Abstract excerpt
We aim to develop a formula based on single nucleotide polymorphisms (SNPs) to predict whether the propofol target-controlled infusion (TCI) concentration would be over 4 μg mL-1 at the time of loss of consciousness (LOC). We recruited 184 patients undergoing thyroid or breast surgeries with propofol anaesthesia. A total of 48 SNPs of CYP2B6, CYP2C9, UGT1A9, HNF4A, ABCB1, ABCC4, ABCG2, GABRA2, GABRA4, GABRB1,...
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