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Article

Effects of Single Nucleotide Polymorphisms on Surgical and Postsurgical Opioid Requirements: A Systematic Review and Meta-Analysis.

The Clinical journal of pain - 1 Dec 2017

Choi Siu-Wai, Lam David M H, Wong Stanley S C, Shiu Haydn H C, Wang Amy X M, Cheung Chi-Wai

Abstract excerpt

OBJECTIVES: There is great heterogeneity in the way individuals respond to medications. Inherited differences, such as single nucleotide polymorphisms (SNP), can influence the efficacy and toxicity of drugs. This meta-analysis aims to collate data from studies investigating the effect of SNPs on postoperative and/or intraoperative opioid requirements. MATERIALS AND METHODS: A meta-analysis was conducted following...

Read the complete abstract on PubMed

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Share to Analgesics, Opioid
Share to ABCB1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COMT gene

Share to OPRM1 gene

Share to Genetic Predisposition to Disease

Share to Pain, Postoperative

Share to Pharmacogenomic Testing

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 28379874
DOI: 10.1097/AJP.0000000000000498

Genes

ABCB1
COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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