Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.

European journal of pharmacology - 28 Aug 2026

Akan Mikail, Panina Aleksandra, Khandokhin Mikhail, Mohammad Salahuddin, Schiöth Helgi B, Mwinyi Jessica

Abstract excerpt

Pain is one of the most prevalent and challenging symptoms in cancer, and opioids remain central to its management. Genetic factors are thought to underlie interindividual variability in opioid response, yet findings across pharmacogenomic studies have been inconsistent. We conducted a systematic review and seven meta-analyses across 24 independent populations (n = 4190), evaluating the three most frequently...

Topics

Join the communities discussing this publication.

Analgesics, Opioid
ATP Binding Cassette Transporter, Subfamily B
Catechol O-Methyltransferase
CYP3A4 gene
CYP3A5 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Receptors, Opioid, mu

Source

Identifiers

PMID: 42492880
DOI: 10.1016/j.ejphar.2026.179173

Genes

OPRM1
ABCB1
COMT
CYP3A4
CYP3A5
HTR3B
OPRD1
OPRK1
STAT6
UGT2B7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.PMID 42492880Read ↗

Clinical Implications of Opioid Pharmacogenomics in Patients With Cancer.Semantic proximity Read ↗

Pain polymorphisms and opioids: An evidence based reviewSemantic proximity Read ↗

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients.Semantic proximity Read ↗

Review of Opioid Pharmacogenetics and Considerations for Pain ManagementSemantic proximity Read ↗

Effects of Single Nucleotide Polymorphisms on Surgical and Postsurgical Opioid Requirements: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Evidence Regarding Pharmacogenetics in Pain Management and Cancer.Semantic proximity Read ↗

Pharmacogenomics and Patient Treatment Parameters to Opioid Treatment in Chronic Pain: A Focus on Morphine, Oxycodone, Tramadol, and Fentanyl.Semantic proximity Read ↗

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.Semantic proximity Read ↗

Influence of genetic variants of opioid-related genes on opioid-induced adverse effects in patients with lung cancer: A STROBE-compliant observational study.Semantic proximity Read ↗

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene.Semantic proximity Read ↗

Genetics and Opioids: Towards More Appropriate Prescription in Cancer PainSemantic proximity Read ↗

Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.