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Article

Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli.

Microbial cell factories - 25 Mar 2011

Minty Jeremy J, Lesnefsky Ann A, Lin Fengming, Chen Yu, Zaroff Ted A, Veloso Artur B, Xie Bin, McConnell Catie A, Ward Rebecca J, Schwartz Donald R, Rouillard Jean-Marie, Gao Yuan, Gulari Erdogan, Lin Xiaoxia Nina

Abstract excerpt

BACKGROUND: Isobutanol is a promising next-generation biofuel with demonstrated high yield microbial production, but the toxicity of this molecule reduces fermentation volumetric productivity and final titer. Organic solvent tolerance is a complex, multigenic phenotype that has been recalcitrant to rational engineering approaches. We apply experimental evolution followed by genome resequencing and a gene...

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Identifiers

PMID: 21435272
DOI: 10.1186/1475-2859-10-18
PMCID: PMC3071312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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