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Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli.

Molecular systems biology - 21 Dec 2010

Atsumi Shota, Wu Tung-Yun, Machado Iara M P, Huang Wei-Chih, Chen Pao-Yang, Pellegrini Matteo, Liao James C

Abstract excerpt

Escherichia coli has been engineered to produce isobutanol, with titers reaching greater than the toxicity level. However, the specific effects of isobutanol on the cell have never been fully understood. Here, we aim to identify genotype-phenotype relationships in isobutanol response. An isobutanol-tolerant mutant was isolated with serial transfers. Using whole-genome sequencing followed by gene repair and...

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Identifiers

PMID: 21179021
DOI: 10.1038/msb.2010.98
PMCID: PMC3018172

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