Article
PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review.
Liver international : official journal of the International Association for the Study of the Liver - 1 May 2023
Boeckmans Joost, Gatzios Alexandra, Schattenberg Jörn M, Koek Ger H, Rodrigues Robim M, Vanhaecke Tamara
Abstract excerpt
BACKGROUND: It is unclear whether the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C-to-G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regression of hepatic steatosis when treating non-alcoholic fatty liver disease (NAFLD). OBJECTIVES: Investigate if carriage of the PNPLA3 148M allele affects the...
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