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Article

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.

Current pharmaceutical design - 1 Jan 2013

Dongiovanni Paola, Anstee Quentin M, Valenti Luca

Abstract excerpt

Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver disease (NAFLD) which, when associated with oxidative hepatocellular damage, inflammation, and activation of fibrogenesis, i.e. non-alcoholic steatohepatitis (NASH), can progress towards cirrhosis and hepatocellular carcinoma. Due to the epidemic of obesity, NAFLD is now the most frequent liver disease and the leading...

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Identifiers

PMID: 23394097
DOI: 10.2174/13816128113199990381
PMCID: PMC3850262

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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