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Article

Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial.

Journal of hepatology - 1 Dec 2015

Scorletti Eleonora, West Annette L, Bhatia Lokpal, Hoile Samuel P, McCormick Keith G, Burdge Graham C, Lillycrop Karen A, Clough Geraldine F, Calder Philip C, Byrne Christopher D

Abstract excerpt

BACKGROUND & AIMS: Genetic variation in both patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) influences severity of liver disease, and serum triglyceride concentrations in non-alcoholic fatty liver disease (NAFLD), but whether either genotype influences the responses to treatments is uncertain. METHODS: One hundred three...

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Source

Identifiers

PMID: 26272871
DOI: 10.1016/j.jhep.2015.07.036

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial.PMID 26272871Read ↗

Reduction of Caloric Intake Might Override the Prosteatotic Effects of the PNPLA3 p.I148M and TM6SF2 p.E167K Variants in Patients with Fatty Liver: Ultrasound-Based Prospective Study.Semantic proximity Read ↗

Patatin-Like Phospholipase Domain-Containing Protein 3 I148M and Liver Fat and Fibrosis Scores Predict Liver Disease Mortality in the U.S. Population.Semantic proximity Read ↗

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects.Semantic proximity Read ↗

Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

Analysis of TM6SF2, PNPLA3, and ATG16L1 Genetic Variants in MASLD and MASH: An Egyptian Case-control StudySemantic proximity Read ↗

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2.Semantic proximity Read ↗

Metabolic effects of risk alleles in <i>PNPLA3, TM6SF2, GCKR</i> and <i>LYPLAL1</i> inform about heterogeneity of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver diseaseSemantic proximity Read ↗

PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review.Semantic proximity Read ↗

Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.Semantic proximity Read ↗

Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population.Semantic proximity Read ↗

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.Semantic proximity Read ↗

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