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Article

Association of genetic variants in six candidate genes with valproic acid therapy optimization.

Pharmacogenomics - 1 Aug 2011

Hung Chin-Chuan, Ho Jia-Ling, Chang Wei-Lun, Tai John Jen, Hsieh Tsung-Jen, Hsieh Yow-Wen, Liou Horng-Huei

Abstract excerpt

AIMS: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. The aim of the study was to investigate whether polymorphisms in genes related to pharmacokinetic and pharmacodynamic pathways of VPA were associated with the large interindividual variability in dosages and concentrations. METHODS & RESULTS: Genetic polymorphisms in six candidate genes were detected in 162 epileptic patients under...

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Identifiers

PMID: 21806385
DOI: 10.2217/pgs.11.64

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