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Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.

Epilepsy research - 1 May 2017

Wang Can, Wang Ping, Yang Li-Ping, Pan Jing, Yang Xue, Ma Hong-Ying

Abstract excerpt

OBJECTIVE: To explore the influence of CYP2C9, CYP2A6, ACSM2A, CPT1A gene polymorphisms on valproic acid (VPA) and its role in metabolism-related liver dysfunction in order to guide the clinical safety and rational use of VPA. METHODS: One hundred two patients taking sodium valproate oral solution were genotyped. To assess the genotypes of relevant genes, the CYP2C9 gene was directly sequenced; for polymorphism...

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PMID: 28315807
DOI: 10.1016/j.eplepsyres.2017.02.015

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