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Article

Investigation of the Association Between the ITPA Gene 94C>A Gene Sequence Variant and Liver Transplant Rejection in Iranian Liver Transplant Recipients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Dec 2022

Heidari Mozhdeh, Khalili Marzieh, Malek Hosseini Seyed Ali, Geramizadeh Bita, Shamsaefar Ali Reza, Balouchi Fardin, Karimi Mohammad Hossein

Abstract excerpt

OBJECTIVES: Inosine triphosphate pyrophosphatase is an enzyme encoded by the ITPA gene and functions to prevent the incorporation of thiopurine nucleotides into DNA and RNA. Thiopurine drug metabolites such as azathioprine and 6-mercaptopurine have been included in the lists of inosine triphosphate pyrophosphatase substrates. Inosine triphosphatase gene alterations are other pharmacogenetic sequence variants...

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PMID: 36718008
DOI: 10.6002/ect.2022.0362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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