Article
The influence of CTLA-4 single nucleotide polymorphisms on acute kidney allograft rejection in Turkish patients.
Clinical transplantation - 1 Jul 2015
Ruhi Çağlar, Sallakçi Nilgün, Yeğin Olcay, Süleymanlar Gültekin, Ersoy F Fevzi
Abstract excerpt
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a cell surface protein, which down-regulates the immune response at CTLA-4/CD28/B7 pathway. We aimed to investigate the influence of the -318 C/T, +49 A/G, -1661 A/G and CT60A/G, and CTLA-4 gene polymorphisms on acute rejection of kidney allograft in Turkish patients. The study design was a case-control study that consists of three groups: Group 1 (n = 34) represented...
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