Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population.

Drug metabolism and personalized therapy - 1 Mar 2024

Deva Reka, Rajendran Priyadharsini, Ramasamy Sivaranjini, Selvan Senthamizh, Ramasamy Kesavan

Abstract excerpt

OBJECTIVES: Azathioprine (AZA) is an effective immunosuppressant commonly used for malignancy and immune-mediated disorders. The association between genetic polymorphisms and AZA-induced adverse effects has not been elucidated. Hence this study aimed to evaluate the relationship between single nucleotide polymorphisms of ITPA (C94A) with azathioprine-induced adverse effects. METHODS: A cross-sectional study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azathioprine
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug-Related Side Effects and Adverse Reactions

Share to Genotype

Share to Immunosuppressive Agents

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 38097396
DOI: 10.1515/dmpt-2023-0061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population.PMID 38097396Read ↗

Frequency of pharmacogenomic variants affecting safety and efficacy of immunomodulators and biologics in a South Asian population from Sri Lanka.Semantic proximity Read ↗

SNPs affecting the clinical outcomes of regularly used immunosuppressants.Semantic proximity Read ↗

ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.Semantic proximity Read ↗

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.Semantic proximity Read ↗

Mutation in the ITPA gene predicts intolerance to azathioprine.Semantic proximity Read ↗

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).Semantic proximity Read ↗

A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.Semantic proximity Read ↗

HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.Semantic proximity Read ↗

Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprineSemantic proximity Read ↗

Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.Semantic proximity Read ↗

Association of CTLA4 exon-1 polymorphism with the tumor necrosis factor-α in the risk of systemic lupus erythematosus among South Indians.Semantic proximity Read ↗

Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.