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Article

Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients.

Fundamental & clinical pharmacology - 1 Jun 2010

Xiong Hui, Xin Hua-Wen, Wu Xiao-Chun, Li Qing, Xiong Lei, Yu Ai-Rong

Abstract excerpt

Azathioprine (AZA) is a thiopurine prodrug commonly used in patients with kidney transplantation. The aim of this study is to explore in patients with kidney transplantation whether AZA-related side effects can be explained by the inosine triphophate pyrophosphatase (ITPA) or thiopurine S-methyltransferase (TPMT) polymorphisms using both pheno-and genotyping. Erythrocyte ITPA and TPMT activity of 155 patients...

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Source

Identifiers

PMID: 19682085
DOI: 10.1111/j.1472-8206.2009.00770.x

Genes

ITPA
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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