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Article

Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.

Human molecular genetics - 18 May 2023

Qannan Abeer, Bejaoui Yosra, Izadi Mahmoud, Yousri Noha A, Razzaq Aleem, Christiansen Colette, Martin George M, Bell Jordana T, Horvath Steve, Oshima Junko, Megarbane Andre, Ericsson Johan, Pourkarimi Ehsan, El Hajj Nady

Abstract excerpt

Berardinelli-Seip congenital lipodystrophy type 2 (CGL2) is a very rare human genetic disorder with potential significance to the understanding of the pathobiology of aging. CGL2 patients display characteristic progeroid features and suffer from type 2 diabetes, insulin resistance and fatty liver. In this study, we profiled genome-wide DNA methylation levels in CGL2 patients with BSCL2 mutations to study...

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Share to Aging
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to GTP-Binding Protein gamma Subunits

Share to Lipodystrophy

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Source

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Identifiers

PMID: 36715159
DOI: 10.1093/hmg/ddad016
PMCID: PMC10196674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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