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Article

DNA methylation signatures in Blood DNA of Hutchinson-Gilford Progeria syndrome.

Aging cell - 1 Feb 2022

Bejaoui Yosra, Razzaq Aleem, Yousri Noha A, Oshima Junko, Megarbane Andre, Qannan Abeer, Potabattula Ramya, Alam Tanvir, Martin George M, Horn Henning F, Haaf Thomas, Horvath Steve, El Hajj Nady

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder caused by mutations in the LMNA gene and characterized by premature and accelerated aging beginning in childhood. In this study, we performed the first genome-wide methylation analysis on blood DNA of 15 patients with progeroid laminopathies using Infinium Methylation EPIC arrays including 8 patients with classical HGPS. We could...

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Identifiers

PMID: 35045206
DOI: 10.1111/acel.13555
PMCID: PMC8844112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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