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Article

Towards a mechanistic understanding of lipodystrophy and seipin functions.

Bioscience reports - 2 Oct 2014

Wee Kenneth, Yang Wulin, Sugii Shigeki, Han Weiping

Abstract excerpt

CGL (Congenital generalized lipodystrophy) is a genetic disorder characterized by near complete loss of adipose tissue along with increased ectopic fat storage in other organs including liver and muscle. Of the four CGL types, BSCL2 (Berardinelli-Seip Congenital lipodystrophy type 2), resulting from mutations in the BSCL2/seipin gene, exhibits the most severe lipodystrophic phenotype with loss of both metabolic...

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Source

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Identifiers

PMID: 25195639
DOI: 10.1042/BSR20140114
PMCID: PMC4182903

Genes

BSCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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